What is use of bispecific Abs?

Genetically engineered antibodies that bind simultaneousl to 2 different antigen epitopes: — Both on tumor cell: higher specificity — One on the tumor cell + One on an immune cell (Ex: CD3): potentiation of cellular immunity — Atumaxomab (Removab®) was the first approved T cellengaging BsAb for the treatment of malignant ascites; it was approved initially in 2009 and is currently used worldwide