The development of a vaccine against malaria has been very difficult

Plasmodium is a eukoryotic organism and therefore has many genes, can code for a wide variety of surface antigens many life cylce within humans, each one having different surface antigens plasmodium also lives inside red blood cells and cells of the liver. surrounded by the membrane of the host cells, it does not cause an immune response from the lymphocytes of the body's immune systeem, equally any antibodies present in the blood cannot work against the stages of plasmodium that occur within cells.