Toxic blood levels of the drug may be due to repeated injections or could result from a single inadvertent IV injection. Aspiration before every injection is paramount to safety. The signs, symptoms, and timing of local anesthetic systemic toxicity are unpredictable. The most important step in treating local anesthetic toxicity is to consider the diagnosis in any patient with altered mental status or cardiovascular instability following injection of local anesthetic. CNS symptoms (either excitation or depression of the CNS) may be apparent but may also be subtle, nonspecific, or absent. Treatment for systemic local anesthetic. toxicity includes airway management, support of breathing and circulation, seizure suppression, and, if needed, cardiopulmonary resuscitation. Administering a 20-percent lipid emulsion infusion (lipid rescue therapy) is a promising asset in treating local anesthetic toxicity.