L-12 Modeling protein Structure: What are the properties of homology modeling?

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What are the properties of homology modeling?

Shay 1vcc · Accepted Answer

Simplest, reliable approach
Basis: proteins with similar sequences tend to fold into similar structures
Has been observed that even proteins with 25% sequence identity fold into similar structures
Does not work for remote homologs (< 25% pairwise identity)

L-12 Modeling protein Structure

What are the properties of homology modeling?

Simplest, reliable approach Basis: proteins with similar sequences tend to fold into similar structures Has been observed that even proteins with 25% sequence identity fold into similar structures Does not work for remote homologs (< 25% pairwise identity)

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