L-12 Modeling protein Structure: What is the approach of homology modeling?

Question

What is the approach of homology modeling?

Shay 1vcc · Accepted Answer

• Given:
• A query sequence Q
• A database of known protein structures
• Find protein P such that P has high sequence similarity to Q • Return P’s structure as an approximation to Q’s structure

L-12 Modeling protein Structure

What is the approach of homology modeling?

• Given: • A query sequence Q • A database of known protein structures • Find protein P such that P has high sequence similarity to Q • Return P’s structure as an approximation to Q’s structure

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