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MBS1002 Biomedical Approaches

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Question:

What are the differences in speed and spatial resolution between MALDI, DESI and SIMS?

Author: Mirte Schattorie



Answer:

The spatial resolution of SIMS is the best out of the three. then comes MALDI and then DESI. but the higher the resolution, the smaller the amount of sample that can be ionized at the time. DESI is the fastest out of the three. SIMS takes quite a lot of time, MALDI is quite fast but time is lost in preparing the matrix.


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