How is presentation of HL?

• Nodular Sclerosis (most common subtype) Collagen bands that divide lymph nodes into circumscribed nodules Lacunar variant RS cells • Mixed-cellularity T cells, eosinophils, plasma cells, macrophages, RS cells, EBV • Lymphocyte-rich Reactive lymphocytes most of cellular infiltrate, EBV • Lymphocyte depletion Paucity of lymphocytes, EBV  ! Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) Non-classical RS cells- L&H variants (popcorn cell) Most important is RS cells